Tirzepatide VS semaglutide

Tirzepatide and semaglutide are both injectable medications used for weight loss and type 2 diabetes management, but they differ in their mechanisms of action and effectiveness. Here’s a comparison of the two drugs:

Mechanism of Action​

Tirzepatide:

• Dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist
• Activates both GIP and GLP-1 receptors

Semaglutide:

• Selective GLP-1 receptor agonist
• Activates only GLP-1 receptors

Effectiveness for Weight Loss​

Tirzepatide:

• Associated with greater weight loss compared to semaglutide
• In a study of adults with overweight or obesity:
  • Patients were 1.76 times more likely to achieve ≥5% weight loss
  • 2.54 times more likely to achieve ≥10% weight loss
  • 3.24 times more likely to achieve ≥15% weight loss compared to semaglutide

Semaglutide:

• Effective for weight loss, but generally less so than tirzepatide
• Approved for chronic weight management in adults with obesity or overweight with at least one weight-related condition

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